A modern take on the classic Alice in Wonderland, this tale follows the adventures of the modern day Alice Hamilton, a fiercely independent 20-something who suddenly finds herself on the other side of a looking glass.

The story takes place in Wonderland 150 years after the original "Alice's" visit.

Wonderland is now an outlandish city of twisted towers and casinos built out of playing cards, all under the rule of the Queen of Hearts (Kathy Bates). The White Rabbit is a secret organization that works for the Queen of Hearts and abducts people from the real world (referred to as "Oysters"), so they can gamble in the Queen's casino. Once people are kidnapped, they are sedated and forced to play in the casino so their emotions can be drained by the Queen. These drained emotions have a drug-like effect on the people of Wonderland. The Queen keeps people under control by sedating them with elixirs that provide an instant fix of emotions as a way to pacify them when they become too unruly.

With the arrival of Alice and the possible upheaval she might cause to her ruling, the enraged Queen orders the White Rabbit to find and capture Alice.

In the course of her adventure, Alice enlists the help of an array of characters including the resistance fighter Hatter, resistance leader Dodo and the White Knight.